Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CTDNEP1 contributors: mct - updated : 28-03-2023
HGNC name dullard homolog (Xenopus laevis)
HGNC id 19085
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C-terminal conserved domain of NLI-IF (Nuclear LIM Interactor-Interacting Factor)
  • HOMOLOGY
    interspecies homolog to rattus Rn.4211
    homolog to murine Dullard
    homolog to Xenopus Xl.5594
    homolog to Zebrafish Dr.7581
    homolog to Drosophila CG1696
    homolog to C.elegans F45E12.1
    Homologene
    FAMILY
  • DXDX(T/V) phosphatase family
  • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    intracellular,nuclear envelope
    basic FUNCTION
  • playing a necessary role for neural development
  • involved in neural development, and functioning as a negative regulator of BMP signaling
  • promotes BMPR degradation via the lipid raft-caveolar pathway
  • dephosphorylates LPIN1, LPIN2, LPIN3, and potentially participates in a unique phosphatase cascade regulating nuclear membrane biogenesis, cascades conserved from yeast to mammals (
  • having specificity for the peptide corresponding to the insulin-dependent phosphorylation site (Ser106) of lipin
  • is essential for ovarian homeostasis at least in part via suppression of BMP signaling
  • CTDNEP1, controls de novo glycerolipid synthesis through lipin to prevent invasion of excess ER membranes into NE holes and a defective nuclear envelope (NE) permeability barrier
  • CTDNEP1-EPS8L2 interaction regulates likely dorsal actin cables for nuclear movement during cell migration
  • CTDNEP1 is a tumor suppressor in highly aggressive MYC-driven medulloblastomas by controlling MYC activity and mitotic fidelity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text neural development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with BMP type I receptors and represses the BMP-dependent phosphorylation of the BMP type I receptor
  • interacting with LPIN1, LPIN2, LPIN3 (Lipin cellular location, protein partners, and biological function are directed by phosphorylation-dephosphorylation events catalyzed by the phosphoserine phosphatase CTDNEP1)
  • encodes a phosphatase that suppresses BMP signaling by inactivating or degrading BMP receptors
  • CTDNEP1 and EPS8L2 directly interact, and this interaction is important for nuclear positioning and cell migration
  • CTDNEP1 counteracts MTOR kinase to establish a dephosphorylated pool of the phosphatidic acid phosphatase lipin 1 in interphase
  • TDNEP1 control of LPIN1 limits the synthesis of fatty acids for ER membrane biogenesis in interphase that then protects against chromosome missegregation in mitosis
  • CTDNEP1 post-translationally modulates the activities of key regulators for chromosome segregation and mitotic checkpoint regulators including topoisomerase TOP2A and checkpoint kinase CHEK1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS