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FLASH GENE
Symbol ELAVL1 contributors: mct/npt/pgu - updated : 16-09-2016
HGNC name ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
HGNC id 3312
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three copies of the RNP motif, binding to AU-rich elements (ARE), of early response-gene messenger
  • a HNS signal (HUR nuclear cytoplasmic shuttling sequence)
  • an RNA-binding region containing two N-terminal RNA-recognition motif domains bound to an 11-base RNA fragment
  • HOMOLOGY
    Homologene
    FAMILY
  • RRM ELAV (embryonic lethal abnormal vision) family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • localizes first to the nucleus and then to the cytoplasm during muscle differentiation
  • predominantly nuclear RNA-binding protein, but translocates to the cytoplasm in response to stress and proliferative signals, where it stabilizes or modulates the translation of target mRNAs
  • during apoptosis, however, ELAVL1 accumulates in the cytoplasm
  • interacts with TNPO2 and thus blocks the re-import of ELAVL1 into the nucleus
  • is tyrosine-phosphorylated by JAK3, leading to modification of subcytoplasmic localization
  • basic FUNCTION
  • shuttling the ERG class of mRNA to the cytoplasm in response to regulatory signals, where they become stabilized, translated or rapidly degraded
  • key mediator of posttranscriptional regulation and expression of the SLC11A1 gene
  • involved in the regulation of protein synthesis
  • functions as a repressor of HIV-1 IRES activity and acts as an activator of the HCV IRES
  • has a role in the post-transcriptional regulation of HCV and HIV-1 gene expression
  • important regulator of gene expression, controlling the localization, stabilization, and translation of many different mRNAs
  • seems to play a positive role in both regulation of BCL2 mRNA translation and mRNA stability
  • RNA-binding protein regulating the stability and translation of numerous mRNAs encoding stress-response and proliferative proteins
  • is an essential regulator of mesenchymal responses during lung branching
  • stabilizer of mRNA, having important roles in regulating the localization, translation, and stability of its targets, thus having a substantial ability to impact gene expression
  • involvement during spermatogenesis
  • implicated in a variety of biological processes as well as being linked with a number of diseases, including cancer (pMID: 21890634)
  • facilitates RBM38-mediated growth suppression by repressing MYC expression
  • CELF1 and ELAVL1 jointly regulate the translation of occludin and play a crucial role in the maintenance of tight junction (TJ) integrity in the intestinal epithelial cell monolayer
  • is a post-transcriptional factor, which acts mainly as a positive regulator of gene expression by binding to specific mRNAs whose corresponding proteins are fundamental for key cellular functions
  • SQSTM1 is decreased through autophagy-mediated degradation, while ELAVL1 through the proteasomal pathway
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • component of BCL2 messenger ribonucleoprotein (mRNP) complexes
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • interacting with HADHB, REN, PCBP1
  • interaction with ATF2 (ELAVL1 silencing rendered the ATF2 mRNA unstable and prevented increases in ATF2 mRNA and protein)
  • interacting with TNPO2 (ELAVL1 is localized to the nucleus of myoblasts by active TNPO2-mediated import)
  • interacting with PTGS2 (can stabilize the mRNA of PTGS2, and cytoplasmic expression of ELAVL1 is associated with increased PTGS2 expression in some cancers)
  • polyamines modulate the stability of JUND mRNA in intestinal epithelial cells through ELAVL1 and HNRNPD
  • ZNF385A regulates TP53 expression in cooperation with ELAVL1
  • ELAVL1 bind and control the FGF10 and TBX4 mRNAs
  • interacting with TNPO2 (normally responsible for the nuclear import of the RNA-binding protein ELAVL1)
  • HSPA2 is a target for ELAVL1
  • HNRNPD and ELAVL1 bind to VEGF ARE RNA under both normoxic and hypoxic conditions
  • ELAVL1 is a target of RBM38 and a mediator of RBM38-induced growth suppression
  • promotes OCLN translation by blocking occludin mRNA translocation to P-bodies via the displacement of ELAVL1
  • RNA-dependent interactions of RALY with MATR3, PABPC1 and ELAVL1
  • CARM1 represses replicative senescence by methylating ELAVL1 and thereby enhancing ELAVL1 ability to regulate the turnover of CCNA1, CCNB1, FOS, SIRT1, and CDKN2A mRNAs (
  • CARM1 catalyzes the methylation of ELAVL1
  • ELAVL1 is a novel posttranscriptional regulator of ABCA1 expression and cellular cholesterol homeostasis
  • complex role for HSF1 in the regulation of ELAVL1 and CTNNB1 expression that may be significant in mammary carcinogenesis
  • ELAVL1 and PARN destabilize Cat2 transcribed nuclear RNA (Ctn RNA) in absence of ADARB1, indicating that ADARB1 stabilizes Ctn RNA by antagonizing its degradation by PARN and ELAVL1
  • ELAVL1 stabilizes ATP6V0D2 mRNA, which is required for the TLR3-mediated innate immune responses
  • critical role of ELAVL1 in regulating lipid transport and ATP synthesis, by regulating the splicing of APOB mRNA and the translation of UQCRB and NDUFB6
  • cell & other
    REGULATION
    inhibited by RNASEL (overexpression of RNASEL decreases cellular growth and downmodulates the RNA-binding protein, ELAVL1, a regulator of cell-cycle progression and tumorigenesis)
    Other phosphorylated by CDK1 during G2, thereby helping to retain it in the nucleus in association with 14-3-3 and hindering its post-transcriptional function and anti-apoptotic influence
    regulated by polyamines (regulate the subcellular localization of the RNA-binding protein ELAVL1, which stabilizes its target transcripts such as nucleophosmin and TP53 mRNAs)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS