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FLASH GENE
Symbol RIC8A contributors: mct - updated : 05-05-2015
HGNC name resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)
HGNC id 29550
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • synembryn family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome,centromere
    text during mitosis, localized at the cell cortex, spindle poles, centromeres, central spindle, and midbody
    basic FUNCTION
  • RIC8A, RIC8B act together with GNAQ regulating neuronal transmitter release
  • GEF (guanine nucleotide exchange factor) for several alpha subunits of heterotrimeric GTP binding proteins (Galpha proteins)
  • acting as a guanine nucleotide exchange factor, catalyzes the release of GDP from various Galpha
  • its signaling leads to assembly of a cortical signaling complex that functions to orient the mitotic spindle
  • nonreceptor guanine nucleotide exchange factor
  • with RGS14 are recruited from the cytosol to the plasma membrane in the presence of coexpressed GNAI1 in cells, suggesting formation of a functional protein complex with GNAI1
  • RIC8A and and RIC8B are guanine nucleotide exchange factors that enhance different heterotrimeric guanine nucleotide-binding protein (G protein) signaling pathways
  • RIC8A and RIC8B are molecular chaperones required for the initial association of nascent Galpha subunits with cellular membranes
  • RIC8A, RIC8B act as non-receptor GEF activators of G proteins in signal transduction contexts will be weighed against the evidence supporting the molecular chaperoning function of RIC8 in promoting G protein abundance
  • molecular chaperoning function of RIC8A is to participate in the folding of nascent G protein alpha subunits
  • RIC8A, RIC8B directly participates in the posttranslational folding of nascent Galpha subunits to promote G-protein biosynthesis
  • plays essential roles during the migration of cranial neural crest (NC) cells, possibly by regulating cell adhesion and spreading
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between the N-terminus of ADCY5 and RIC8A provides a novel pathway to fine-tune ADCY5 activity via a GNAI1-mediated pathway
  • RGS14 and RIC8A share an overlapping binding region within the last 11 amino acids of GNAI1
  • NCAM1 regulates RIC8A membrane localization and potentiates beta-adrenergic response
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • in mice the activity of Ric8a in neurons is essential for survival and its deficiency causes a severe neuromuscular phenotype