Selected-GenAtlas references SOURCE GeneCards NCBI Gene Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TMEM259 contributors: mct - updated : 19-03-2020
HGNC name transmembrane protein 259
HGNC id 17039
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal and 5 C-terminal transmembrane domains
  • potential sites for N-myristoylation and for phosphorylation
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • critical role of membralin in motor neuron survival, suggesting a novel mechanism for early-onset motor neuron disease
  • is an ERAD component, whith a reduction of mRNA and protein levels in Alzheimerdisease (AD) brain, suggesting a critical role for ERAD in Alzheimer pathogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in ovarian serous carcinomas, in effusion carcinoma, higher than in solid tumor, as compared to ovarian surface epithelium
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS