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FLASH GENE
Symbol DHX36 contributors: mct - updated : 07-03-2013
HGNC name DEAH (Asp-Glu-Ala-His) box polypeptide 36
HGNC id 14410
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal region is essential for binding G4 structures and further identify within this region the evolutionary conserved RSM (RHAU-specific motif) domain as a major affinity and specificity determinant
  • two DRBM (double-stranded rna-binding) domains
  • HOMOLOGY
    Homologene
    FAMILY
  • DEAD box helicase family
  • DEAH subfamily
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be playing a role in X-linked gene expression
  • is responsible for the majority of tetramolecular G4-DNA resolvase activity
  • fourth RNA helicase detected in stress granules (SGs), after DDX6, DDX3, and EIF4A, and its association with SGs is dynamic and mediated by an DHX36-specific RNA-binding domain
  • its helicase activity is sufficient to unwind the quadruplex and promote an interaction with 25 internal nucleotides to form a stable P1 helix
  • is the only helicase having G-quadruplex (G4)-RNA resolvase activity and the major source of G4-DNA resolvase activity
  • may potentially play a role in the regulation of gene expression that relies on its G4 resolvase activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • DDX1-DDX21-DHX36 complex represents a dsRNA sensor that uses the TICAM1 pathway to activate type I IFN responses in the cytosol of myeloid dendritic cells (mDCs)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the N-terminal accessory domain of DHX36 known to bind specifically to the parallel-strand G-quadruplex substrates resolved by the helicase domain
  • TERC is a true target of DHX36
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS