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FLASH GENE
Symbol SC5DL contributors: - updated : 01-07-2006
HGNC name sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like
HGNC id 10547
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal cytochrome b(5)-like domain as well as three histidine-rich domain
  • histidine box domain containing the active site for metal ion binding
  • HOMOLOGY
    interspecies homolog to fungal
    homolog to murine Sc5d
    Homologene
    FAMILY sterol desaturase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • involved in cholesterol biosynthesis
  • catalyzing a dehydrogenation to introduce C5-6 double bond into lathosterol
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    iron
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LTSL
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS