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FLASH GENE
Symbol DCBLD2 contributors: mct/npt - updated : 15-06-2009
HGNC name discoidin, CUB and LCCL domain containing 2
HGNC id 24627
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one CUB domain
  • a coagulation factor V/VIII homology domain
  • an LCCL domain
  • one MAM domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Esdn-pending
    homolog to rattus Esdn
    Homologene
    FAMILY
  • neuropilin family
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • playing a role in regulation of vascular cell growth
  • may have a wide variety of functions in other tissues including the nervous system like neuropilins
  • plays a role in cell motility, whereas they also showed that at least one of its ligands is SEMA4B and that their interaction mediates proteasome degradation by DCBLD2 (Nagai 2007)
  • marker of vascular remodeling and regulator of vascular smooth muscle cell proliferation (Sadeghi 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SEMA4B (regulation of DCBLD2 protein by ubiquitination and proteasome degradation enhanced in the presence of SEMA4B)(Nagai 2007)
  • cell & other
    REGULATION
    induced by in platelet-derived growth factor-BB-stimulated vascular smooth muscle cells in vitro and neointima of the balloon-injured carotid artery in vivo
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in metastatic lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • may become a target of therapy to inhibit metastasis of lung cancers (Nagai 2007)
  • may serve as a therapeutic or diagnostic target for graft arteriosclerosis (Sadeghi 2007)
  • ANIMAL & CELL MODELS