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FLASH GENE
Symbol FRS2 contributors: mct/npt - updated : 02-10-2018
HGNC name fibroblast growth factor receptor substrate 2
HGNC id 16971
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal myristylation sites for localization to membranes, including the plasma membrane
  • a phosphotyrosine binding (PTB) domain for binding to RTKs, such as the fibroblast growth factor (FGF) receptor and neurotrophin receptor
  • four potential GRB2-binding sites
  • HOMOLOGY
    intraspecies homolog to FRS3
    Homologene
    FAMILY
    CATEGORY adaptor , signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • functioning as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation
  • playing a role in the induction of lens and retina through recruitment of FGF and PTPN11
  • plays a pivotal role in FGF-dependent activation of the Ras-MAP kinase, PI-3 kinase, and FRAP1 pathways in breast carcinoma cells
  • central mediator in FGF signaling (Minegishi 2009)
  • FGF/FRS2&
  • 945;-mediated signals prevent premature differentiation of heart progenitor cells through suppressing autophagy.
  • is an adaptor protein that plays a critical role in FGFR signaling
  • FRS2-PTPN11 complex is the key mediator of FGF signaling in lens development
  • is a previously unidentified component of VEGF receptors signaling
  • FRS2 signaling is critical for nephron progenitors
  • is an FGF receptor-associated protein required for activation of downstream signaling molecules that include those in the mitogen-activated protein and AKT1 kinase pathways
  • FRS2, FRS3 may act as an important node for FGF and neurotrophin signaling in postnatal hippocampal development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • FGFR/FRS2 signaling may play a functional role in the development of high-grade liposarcomas
  • central mediator for fibroblast growth factor signaling
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to GRB2 in response to FGF or nerve growth factor stimulation
  • bind to a tyrosine phosphatase, SHP2 (Minegishi 2009)
  • regulates ERK levels to control a self-renewal target HES1 and proliferation of FGF-responsive neural stem/progenitor cells
  • tyrosine phosphorylation of FRS2 mediates FGFR-dependent lens cell survival, providing a mechanistic basis for the unique fiber-differentiating capacity of FGFs on mammalian lens epithelial cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    consistently amplified in classic and dedifferentiated low-grade osteosarcoma (LGOS) but not in their histologic mimics
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • overexpressed FRS2 is a biomarker for Postate carcinoma diagnosis, prognosis and response to therapies
  • Therapy target
    ANIMAL & CELL MODELS