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FLASH GENE
Symbol SPINK7 contributors: SGE - updated : 03-05-2008
HGNC name serine peptidase inhibitor, Kazal type 7 (putative)
HGNC id 24643
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Kazal-like domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • localized to centrosomes during interphase and kinetochores during mitosis
  • secreted
  • basic FUNCTION
  • acting as a serine protease inhibitor
  • contributes to chromosome stability via regulating centrosome amplification and spindle assembly checkpoint
  • participating in centrosome amplification in a TP53-dependent manner
  • playing an important role for ensuring centrosome duplication, spindle assembly checkpoint, and accurate chromosome segregation, and its depletion may contribute to chromosome instability and aneuploidy in cancers
  • regulates cell migration/invasion through PLAUR/beta1 integrins pathway (Cheng 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to MT2A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS