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FLASH GENE
Symbol PSMD14 contributors: mct - updated : 09-11-2016
HGNC name proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
HGNC id 16889
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminus of PSMD14 mediates the binding to MITF and is sufficient to increase MITF transcriptional activity
  • JAB/MPN domain
  • a JAMM motif, essential for cell viability and mutations in the JAMM motif reduced MITF activation of promoters
  • HOMOLOGY
    interspecies homolog to yeast pad1
    Homologene
    FAMILY
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • responsible for substrate deubiquitination during proteasomal degradation
  • is responsible for substrate deubiquitination during proteasomal degradation
  • Ub protease PSMD14 resident in the 19S proteasome regulatory particle is required for processing poly-Ub formed in the DSB response
  • proteasomal PSMD14 is a key de-ubiquitinating enzyme that regulates ubiquitin conjugates generated in response to damage
  • represents a novel component regulating the switch from non-homologous end-joining to homologous recombination
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc dependent protease
    protein
  • binding to TXNL1 (Andersen 2009)
  • PSMD14 and MITF interact in osteoclasts and this interaction is dependent on TNFSF11 signaling
  • acts independently of TP53BP1 in homologous recombination repair to promote RAD51 loading
  • deubiquitylase PSMD14 stabilizes E2F1 protein through binding to and deubiquitylating E2F1 and hyperactivated PSMD14-E2F1 regulation may contribute to the development of liver cancer 6)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in Alzheimer Disease
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS