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FLASH GENE
Symbol PSMD11 contributors: mct - updated : 03-09-2013
HGNC name proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
HGNC id 9556
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one PCI domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Psmd11 (99.8pc)
    homolog to C-Elegans Rpn-6
    homolog to rattus Psmd11 (100.00pc)
    Homologene
    FAMILY
  • proteasome subunit S9 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • acting as a regulatory subunit of the 26s proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
  • has a pivotal role in stabilizing the otherwise weak interaction between the CP (core particle) and the RP (regulatory particle)
  • critical role for the integrity of the 26S proteasomes complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • PA700 complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of AMPK with one of these novel interacting proteins, the non-ATPase subunit of the proteasome PSMD11
  • USP4, a deubiquitylating enzyme with specificity for both Lys48 and Lys63 ubiquitin chains, interacts with the PSMD11 subunit of the proteasome via an internal ubiquitin-like (UBL) domain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS