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FLASH GENE
Symbol FATE1 contributors: mct - updated : 04-01-2012
HGNC name fetal and adult testis expressed 1
HGNC id 24683
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 40-amino acid F-box motif
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • may be a target of SF1 in testicular differentiation and/or germ cell development
  • involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune responses, signaling cascades and developmental events) through target proteins, such as cyclins, cyclin-dependent kinase inhibitors
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other its expression is regulated by steroidogenic factor-1 (SF1) and Wilms tumor protein (WT1), two proteins involved in tumorigenesis, suggesting the role of FATE1 in tumor development
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS