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FLASH GENE
Symbol PPP2R3C contributors: mct - updated : 07-10-2020
HGNC name protein phosphatase 2 (formerly 2A), regulatory subunit B'', gamma
HGNC id 17485
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
two EF-hand domains
HOMOLOGY
Homologene
FAMILY
CATEGORY signaling
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,cytosolic
intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • is involved in the ontogeny of multiple organs, especially critical for testis development and spermatogenesis
  • is a critical intracellular signaling molecule involved in spermatogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PPP2R3C negatively regulates ABCB1 expression and function
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GDRM , SPGF36
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS