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FLASH GENE
Symbol RAD54L2 contributors: mlc/np - updated : 17-11-2007
HGNC name RAD54-like 2 (S. cerevisiae)
HGNC id 29123
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal region mediating interaction with AR
  • HOMOLOGY
    interspecies ortholog to murine Srisnf2l-pending
    Homologene
    FAMILY
    CATEGORY enzyme , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • acting as an helicase
  • active ATPase, and dsDNA (double-stranded DNA) and ssDNA (single-stranded DNA) enhancing its catalytic activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule nucleotide,
    ATP
    protein
  • interacts with AR and binds to DNA and mononucleosomes
  • cell & other
    REGULATION
    Other covalently modified by sumoylation, and mutation of six potential SUMO (small ubiquitin-related modifier) attachment sites abolished its ability to bind DNA, hydrolyse ATP and activate AR function
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS