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FLASH GENE
Symbol MTUS2 contributors: mct/pgu - updated : 06-04-2013
HGNC name microtubule associated tumor suppressor candidate 2
HGNC id 20595
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a leucine-zipper domain at the C-terminus
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text colocalizes with MAPRE1 at the microtubule plus end
    basic FUNCTION
  • facilitating the MAPRE1-dependent loading of KIF2C onto microtubule plus ends and orchestrate the dynamics at the plus ends of microtubules
  • involved in the plus-end localization of KIF2C
  • potential role in development and function of the heart and nervous system in vertebrates
  • microtubule plus-end tracking protein
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to the mitotic centromere-associated kinesin KIF2C
  • interaction with MAPRE1 in loading of KIF2C to the plus ends
  • MAPRE1–MTUS2 interaction coordinates chromosome movements in mitosis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS