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FLASH GENE
Symbol TOX4 contributors: mct - updated : 13-10-2010
HGNC name TOX high mobility group box family member 4
HGNC id 20161
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • HMG box DNA-binding domain
  • C-terminus sufficient for the interaction with an N-terminal region of PPP1R10 that is distinct from its PP1-binding domain
  • HOMOLOGY
    Homologene
    FAMILY HMG-box protein family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in transcription regulation
  • potential role of the PTW/PP1 phosphatase complex in the regulation of chromatin structure during the transition from mitosis into interphase
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component stable multimeric complex composed of regulatory subunits PPP1R10, TOX4, and WDR82 , and PPP1CC catalytic subunit (denoted as the PTW/PP1 phosphatase complex)
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacting with PPP1R10 (transcriptional activity of TOX4 is markedly suppressed by its interaction with PPP1R10, in a PP1-independent manner)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS