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FLASH GENE
Symbol YEATS4 contributors: mct - updated : 18-06-2019
HGNC name YEATS domain containing 4
HGNC id 24859
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to S cerevisiae Anc1
ortholog to murine Yeats4
intraspecies homolog to MLLT3,MLLT1
Homologene
FAMILY YEATS family
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • having a transcription stimulatory activity
  • involved in regulation of transcription, DNA-dependent
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component SWI/SNF complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MLLT1, MLLT3, SMARCB1
  • YEATS4 is a histone acetylation reader that promotes histone H2AFZ deposition in non small cell lung cancer (NSCLC)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in low grade glioma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS