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FLASH GENE
Symbol TSPAN13 contributors: mct/npt - updated : 26-06-2018
HGNC name tetraspanin 13
HGNC id 21643
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • four hydrophobic domains
  • HOMOLOGY
    Homologene
    FAMILY
  • transmembrane 4 superfamily
  • tetraspanin (TM4SF) family
  • CATEGORY regulatory , tumor suppressor , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • mediating signal transduction events that play a role in the regulation of cell development, activation, growth and motility
  • may represent a novel breast cancer suppressor gene (Huang 2005)
  • TSPAN13, TSPAN5 have a reciprocal function during osteoclastogenesis, i.e., positive and negative regulation by TSPAN5 and TSPAN13, respectively
  • may have an important role in the progression of prostate cancer (Arencibia 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in estrogen receptor-negative breast cancers, and expression was lowest in "basal-like" tumors (Huang 2005)
    tumoral     --over  
    in prostate cancer and its expression correlates with factors of favourable outcome (Arencibia 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS