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FLASH GENE
Symbol REPIN1 contributors: mct/pgu - updated : 13-04-2010
HGNC name replication initiator 1
HGNC id 17922
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 15 C2H2 type zinc finger domains organized in three clusters termed hand Z1 (ZFs 1-5), hand Z2 (ZFs 6-8) and hand Z3 (ZFs 9-15)
  • a proline-rich region located between hands Z2 and Z3
  • conjugated PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Repin1 (87.9pc)
    homolog to rattus Repin1 (87.9pc)
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus
    text
  • also located on the ribosome, the nucleus membrane
  • basic FUNCTION
  • identifying origins prior to assembly of pre-initiation complexes
  • polydactyl zinc-finger protein with weak replication enhancing activity and so far unknown cellular function
  • sequence-specific double-strand DNA-binding protein required for initiation of chromosomal DNA replication
  • facilitating DNA bending
  • may act as accessory factors in origin identification prior to the assembly of pre-initiation complexes
  • acts as a sequence-specific DNA binding protein which has a main function as accessory factor in origin identification during DNA replication
  • with geminin act as a previously undescribed repressor complex distinct from REST to negatively regulate the expression of target genes in nonneuronal cells suggesting that the REPIN1-geminin complex may contribute to suppressing the precocious expression of target genes in fetal brain
  • potential role in the regulation of adipocyte size and expression of glucose transporters SLC2A1 and SLC2A4 in adipocytes
  • has weak replication enhancing activity and may act as an accessory factor in origin identification prior to the assembly of pre-initiation complexes
  • regulates the expression of genes involved in adipogenesis, lipid droplet formation and fusion, glucose and fatty acid transport in 3T3-L1 adipocytes
  • potential role as regulator of adipocyte size and seems to be involved in the regulation of genes involved in adipogenesis, lipid droplet formation and fusion, glucose and fatty acid transport in adipocytes
  • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • found in a complex with RP100
  • homodimers or homomultimers
  • INTERACTION
    DNA binding to 5'-ATT-3' reiterated sequences downstream of the origin of bidirectional replication (OBR) and a second, homologous ATT sequence of opposite orientation within the OBR zone
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    obesity  
    potential novel target gene for anti-obesity treatment
    ANIMAL & CELL MODELS