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FLASH GENE
Symbol TRIM45 contributors: mct - updated : 12-07-2017
HGNC name tripartite motif-containing 45
HGNC id 19018
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal RING zinc finger, RING finger domain that is important for localization in the perinuclear region
  • two B-box domains (one type 1 and one type 2)
  • a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
  • a C-terminal (IG-FLMN) (filamin-type immunoglobulin) domain
  • HOMOLOGY
    interspecies homolog to rattus Trim45 (86.4 pc)
    homolog to murine Trim45 (86 pc)
    Homologene
    FAMILY
  • C-X TRIM family
  • RBCC (TRIM family)
  • RING-finger-containing E3 ligases family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    intracellular,nuclear envelope
    text
  • predominantly localized in the perinuclear region
  • basic FUNCTION
  • identifying specific cell compartments
  • may act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway (Wang 2004)
  • inhibiting transcriptional activities of ELK1 and JUN
  • acts likely as a repressor for the NFKB1 signal and regulates cell growth
  • regulates cell proliferation via inhibition in the NFKB1 signaling pathway
  • functions as a member of the negative feedback loop of the MAPK pathway
  • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • may affect cell proliferation via downregulation of NFKB1-mediated transcriptional activity
  • TRIM45 is a novel RACK1-interacting protein and downregulates MAPK signal transduction
  • is a novel tumor suppressor that stabilizes and activates TP53 in glioma
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS