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FLASH GENE
Symbol ANAPC2 contributors: mct - updated : 03-09-2010
HGNC name anaphase promoting complex subunit 2
HGNC id 19989
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C terminal cullin homology domain
    • HOMOLOGY
    Homologene
    FAMILY
  • cullin family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • controlling progresion through anaphase by triggering the degradation of cell cycle regulators such securin and B-type cyclin
  • involved in regulation of axonal growth and synaptic functions in postmitotic neurons
  • orchestrates progression through mitosis by decorating cell-cycle regulators with ubiquitin chains (Jin 2008)
    • CELLULAR PROCESS cell cycle, checkpoint
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    ubiquitin dependent catabolism
    a component
  • member of the anaphase promoting/cyclosome complex (APC/C) is a large E3 ubiquitin ligase containing at least ten different, evolutionarily conserved components
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • inversin (interaction dependent on a conseved D-box motif)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS