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FLASH GENE
Symbol SENP8 contributors: mct/pgu - updated : 14-04-2015
HGNC name SUMO/sentrin specific protease family member 8
HGNC id 22992
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Prsc2
Homologene
FAMILY peptidase family C48
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus
basic FUNCTION
  • involved in the release of sentrins
  • proteases with specificity for hydrolysis of NEDD8 derivatives, playing an unique role in regulating the modification of cullins by NEDD8
  • is a proximal regulator of Cul neddylation and provide an important role for SENP8 in fine-tuning the inflammatory response
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • deconjugating cullin 1 (CUL1)-NEDD8 in a concentration-dependent manner
  • discriminates between NEDD8 and ubiquitin
  • promoted the interaction between E2F1 and its cofactor MCPH1, which is required for TP73 induction
  • key regulator of Cul neddylation response
  • GPS1 targets SENP8 for protein degradation, and GPS1-SENP8 interaction that affects SENP8 protein levels presumably balances cellular deneddylase activity
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS