SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm
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| intracellular,nucleus,nucleoplasm
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| intracellular,nucleus,chromatin/chromosome
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| intracellular,nucleus,nucleolus
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text
| located within nucleus, cytoplasm, dendritic/synaptic terminals, and astrocytic processes |
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highly localized in the cell nucleus of neurons, with some cytoplasm localization as well, and PELP1 is also localized at synaptic sites |
basic FUNCTION
| major keratinocyte cell envelope protein, playing a role in breast cancer tumorigenesis |
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participating in chromatin remodeling activity via displacement of histone 1 in cancer cells |
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promoting and maintaining the hypoacetylated state of histones at the target genomic site, and ER binding reverses its role to hyperacetylate histones through an as yet unidentified mechanism |
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scaffold protein/coactivator which may modulate glucocorticoid actions in the brain ( |
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inhibited transactivation of glucocorticoid receptor (GR) by the ligand-independent activation function (AF)1 but potentiated the COOH-terminal AF2 domain, and likely mediating important cell variation in glucocorticoid responsiveness, in a c-Src-independent mechanism |
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implicated to be important for mediation of both the genomic and nongenomic signaling of 17beta-estradiol (E2) |
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critical for nongenomic and genomic signaling by E2 |
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is a reader of H3 methylation marks and has a crucial role in modulating the histone code at the ESR1 target genes |
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proto-oncogene that functions as an ESR1 co-regulator |
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proto-oncogene PELP1 plays a vital role in rDNA transcription. PELP1 modulation of rRNA transcription, a key step in ribosomal biogenesis may have implications in PELP1-mediated oncogenic functions |
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central role for PELP1 in nonandrogenic activation of the androgen receptor in prostate cancer |
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is a reader of histone arginine methyl modifications and deregulation promotes tumor proliferation via epigenetic alterations at ESR1 target promoters |
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modulates several pathways including the molecular mechanisms of cancer, estrogen signaling, and breast cancer progression |
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is a scaffolding oncogenic protein that functions as a coregulator for a number of nuclear receptors |
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is a novel coregulator of nuclear hormone receptors and is implicated in playing a role in driving breast cancer and enhancing metastatic potential |
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essential role for PELP1 in E2-mediated rapid extranuclear signaling, neuroprotection, and cognitive function in the brain |
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scaffolding protein that functions as a coregulator of several transcription factors and nuclear receptors |
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plays essential roles in several pathways including hormonal signaling, cell cycle progression, ribosomal biogenesis, and the DNA damage response |
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cytoplasmic localization of PELP1 up-regulates pro-tumorigenic IKBKE and secreted inflammatory signals, which through paracrine macrophage activation regulates the migratory phenotype associated with breast cancer initiation |
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is a scaffold protein that interacts with ERs, kinase signaling factors, as well as proteins involved in chromatin remodeling and DNA repair |
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functions as a critical ESR1 coregulator in the brain to mediate E2 signaling and actions |