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FLASH GENE
Symbol ITIH2 contributors: npt/ - updated : 21-06-2006
HGNC name inter-alpha (globulin) inhibitor H2
HGNC id 6167
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a VWFA domain
  • HOMOLOGY
    Homologene
    FAMILY
  • ITIH family
  • CATEGORY regulatory , transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • trypsin inhibitor, acting as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein
  • potentiate the interaction by increasing the avidity of hyaluronan to CD44 and altering their distribution on cell surfaces (Zhuo 2006)
  • contributing to extracellular matrix stability by covalent linkage to hyaluronan (Hamm 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
          --low  
    in 70 p 100 of breast cancer (Hamm 2008)
    tumoral     --low  
    in multiple human solid tumors (Hamm 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS