basic FUNCTION
| regulating the expression of target mRNAs at the translation level |
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may play a role in the proliferation and maintenance of stem cells in the central nervous system |
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required in male meiosis, and has distinct roles at different stages of germ cell differentiation |
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MSI2, and MSI1 affect asymmetric cell division, germ and somatic stem cell function and cell fate determination in various somatic tissues |
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mRNA-binding protein MSI2 influences proliferation and differentiation of HSCs and myeloid progenitors |
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might be a key gene for self-renewal in leukemia |
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distinct roles for Musashi-1 and Musashi-2 in the control of insulin expression and beta-cell proliferation |
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MSI2 is a central component in an unappreciated oncogenic pathway promoting intestinal transformation |
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key function of MSI2 in restricting epithelial cell migration |
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is required for cell survival and optimal osteoclastogenesis by affecting NOTCH1 signaling and NFKB1 activation |
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potent oncogene playing key roles in myeloid leukemia and gastrointestinal malignancies |
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MSI2 maintains quiescent state of Hair follicle stem cells (HFSCs) in the process of the telogen-to-anagen transition |
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MSI1 and MSI2 are emerging as regulators of multiple critical biological processes relevant to cancer initiation, progression, and drug resistance |
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MSI2 RNA-binding proteins (RBPs) is a central regulator of translation of cancer stem cell programs |
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fundamental role for MSI2 in post-transcriptional regulation during male gamete development |
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is a key regulator in stem cells, it is over-expressed in a variety of cancers and its higher expression is associated with poor prognosis |