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FLASH GENE
Symbol TRIOBP contributors: mct - updated : 08-09-2010
HGNC name TRIO and F-actin binding protein
HGNC id 17009
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a pleckstrin homology (PH) domain
  • a coiled-coil region (at least two actin-binding sites per coiled-coil dimer)
    • HOMOLOGY
    interspecies ortholog to murine Triobp
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microfilament
    text
  • localized to F-actin in a periodic pattern
  • cytoskeleton-associated protein localized to rootlets (Kitajiri 2010)
    • basic FUNCTION
  • regulating actin cytoskeletal organisation, cell spreading and cell contraction by directly binding
  • stabilizing filamentous (F)-actin
  • involved in many important fundamental cellular processes, ranging from actin remodeling, directed cell movement, to cell cycle regulation
  • serving as a linker protein to recruit proteins required for F-actin formation and turnover
  • may be involved in mitotic regulation through interacting with TRF1
  • actin-bundling protein that is critical for rootlet formation (Kitajiri 2010)
  • implication in the bundling of actin filaments that is essential for the biogenesis of rootlets providing durable flexibility at the taper and mechanical rigidity to the stereocilia bundle (Kitajiri 2010)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to F-actin, TRIO and myosin II
  • interacting partner of guanine nucleotide exchange factor Trio and TRF1 (TRF1 interacting protein)
  • interacting with HECTD3 (HECTD3 may facilitate cell cycle progression via regulating ubiquitination and degradation of TRIOBP) (Yu 2008)
  • purified TRIOBP interacted with TERF1, suggesting that the purified protein is functional and biologically active (Li 2007)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNB28
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS