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FLASH GENE
Symbol TGM5 contributors: mct/npt - updated : 05-06-2019
HGNC name transglutaminase 5
HGNC id 11781
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Tgm5
Homologene
FAMILY
  • transglutaminase superfamily
  • transglutaminase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,nucleus
    basic FUNCTION
  • catalyzing the cross-linking of proteins and the conjugation of polyamines to proteins
  • contributing to the formation of the cornified cell envelope of keratinocytes
  • having function vital for maintaining cell-cell adhesion between the outermost layers of the epidermis
  • involved in signal transduction and, like two other TGs (TGM3 and TGM5), is able to bind and hydrolyze guanosine triphosphate (Zocchi 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) APSS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS