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FLASH GENE
Symbol IKZF4 contributors: SGE - updated : 12-04-2007
HGNC name IKAROS family zinc finger 4 (Eos)
HGNC id 13179
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six C2H2 type zinc fingers
  • conjugated MetalloP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to chimpanzee ZNFN1A4 (100 pc)
    homolog to murine Zfpn1a4 (95.3 pc)
    Homologene
    FAMILY
  • IKAROS family of transcription factors
  • zinc finger subfamily 1A
  • S1 trypsin-like serine-protease family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • implicated in the control of lymphoid development
  • acting as a transcriptional repressor
  • critical mediator of FOXP3-dependent gene silencing in CD4+ regulatory T cells, via its interaction with FOXP3 and induction of chromatin modifications that result in gene silencing (Pan 2009)
  • may be involved in the development of central and preipheral nervous systems
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • integral component of chromatin-remodeling complexes
  • homo or heterodimerizing with either other member of the family IKZF1, IKZF2, IKZF3 and IKZF5
  • INTERACTION
    DNA binding to typical 5'-GGGAATRCC-3' Ikaros-binding sequences
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with SPI1; MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2
  • interacting with CTBP2
  • interacting with FOXP3 (Pan 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS