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FLASH GENE
Symbol ZNF335 contributors: mct/npt - updated : 24-06-2016
HGNC name zinc finger protein 335
HGNC id 15807
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six C2H2 zinc fingers
  • an LXXLL motif
  • a C-terminal leucine zipper region;
  • N-terminal 35-amino acid region enriched in acidic residues
  • putative protein kinase A
  • tyrosine kinase phosphorylation sites (Mahajan 2002)
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • regulator or coactivator of NRC function
  • enhancing the activity of nuclear hormone receptors as well as other transcription factors such as c-Fos and c-Jun (Garapaty 2009)
  • recruited to the receptor via association with NCOA6, which has been shown to bind directly to liganded RARA (Garapaty 2009)
  • transcriptional regulator that enhances the transcriptional activity of nuclear hormone receptors
  • directs neuronal morphogenesis during early developmental stages through modulating activity-dependent gene transcription
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
  • component of a complex with NCOA6
  • methyltransferase core proteins, ASH2L, RBBP5, and WDR5, form a physically separate complex with ZNF335 (Garapaty 2009)
  • INTERACTION
    DNA binds DNA and drives transcription via recognition of two distinct consensus motifs by separate ZF clusters
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • nuclear hormone receptor (NRC) transactivator
  • interacting with NCOA6 (does not directly interact with nuclear hormone receptors, it enhances activation by nuclear hormone receptors presumably through its interaction with NCOA6) (Garapathy 2009)
  • ZNF335 is a new interacting partner of CDK5R1
  • CDK5R1 interacts with ZNF335 and regulates its nucleocytoplasmic trafficking via the nuclear export pathway
  • binds to promoter regions via a consensus motif, and its target genes are enriched in categories related to protein metabolism, mitochondrial function, and transcriptional regulation and restoring the expression of one target, ANKLE2, partially rescues T cell maturation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCPH10
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mouse mutant, bloto, with a hypomorphic mutation in Zfp335; Zfp335(bloto/bloto) mice exhibit a na
  • ve T cell deficiency due to an intrinsic developmental defect that begins to manifest in the thymus and continues into the periphery