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FLASH GENE
Symbol WDR5B contributors: SGE/npt - updated : 25-06-2010
HGNC name WD repeat domain 5B
HGNC id 17826
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven WD repeats
  • HOMOLOGY
    interspecies homolog to murine Wdr5b (83.8pc)
    homolog to rattus Wdr5b (85.1pc)
    Homologene
    FAMILY
  • WD repeat WDR5/wrds family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may be mediating protein-protein interactions
  • may function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex
  • Ubl conjugation pathway
  • CELLULAR PROCESS cell life
    protein, degradation
    protein, ubiquitin dependent proteolysis
    cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • probable part of a cullin-RING E3 protein ligase complex containing CUL4-DDB1 and a substrate-recruiting component (DCAF)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CUL4 and DDB1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS