basic FUNCTION
| acting as a cysteine-type endopeptidase |
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acting as an ubiquitin thiolesterase |
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required to stabilize CHEK2 and TP53BP1 in response to DNA damage |
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required for MYC stability in tumour cells |
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FBXW7 and USP28 reciprocally regulated cell migration and angiogenesis in an HIF1A-dependent manner  |
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govern the stability of multiple factors that are critical for diverse aspects of the DNA damage response (DDR)  |
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is not a critical factor in double-strand break metabolism and is unlikely to be an attractive target for therapeutic intervention aimed at chemotherapy sensitization  |
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deubiquitinating enzyme that has been implicated in the DNA damage response (DDR), the regulation of MYC signaling and cancer progression  |
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has a chain preference activity for K11, K48 and K63 di-ubiquitin linkages  |