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FLASH GENE
Symbol UBE2N contributors: mct/ - updated : 02-07-2015
HGNC name ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)
HGNC id 12492
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • ubiquitin-conjugating enzyme family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • catalyzing the covalent attachment of ubiquitin to other proteins
  • playing a role in the regulation of stress kinases and of the NF-B pathway
  • playing a critical and unexpected role in the initiation of homologous recombination at the level of DNA double-strand break processing
  • mediates lysine-63-specific protein ubiquitination involved in signal transduction by immune receptors
  • has a cell-intrinsic function in mediating hematopoiesis and is essential for the survival and accumulation of hematopoietic stem cells in the bone marrow
  • UBE2N and UBE2D1 had distinct effects on the conformational dynamics of STUB1, suggesting different roles of the STUB1-E2 interaction in the ubiquitination of substrates and interaction with chaperones
  • only known E2 ubiquitin (Ub)-conjugating enzyme that produces Lys-63-linked Ub chain with its cofactor E2 variant UBE2V1 or UBE2V2
  • UBE2N and STUB1 are novel factors in the regulation of cell surface availability of GHR
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • ubiquitin-conjugating enzyme (E2) that heterodimerizes with UBE2V1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • STK15
  • interacting with TRAF2
  • modifyed by ISG15 (suppresses its ubiquitin-conjugating activity)
  • ZNRF2, interact with UBE2N through its RING finger domain
  • TRAF6 functions together with a ubiquitin-conjugating enzyme complex consisting of UBE2N and UBE2V1 to catalyse Lys 63-linked polyubiquitination, which activates the MAP3K7 kinase complex
  • OTUB1 binding to and inhibiting UBE2N, the cognate E2 enzyme for RNF168 and pharmacological targeting of the OTUB1-UBE2N interaction might enhance the DNA damage response
  • function of TRIM5 is dependent on its association with the E2 ubiquitin-conjugating enzyme complex UBE2N-UBE2V1 and subsequent activation of the MAP3K7 complex and downstream genes involved in innate immune responses
  • RNF8 regulates K48- and K63-linked poly-ubiquitylation via differential RING-dependent interactions with its E2s UBE2L6 and UBE2N, respectively
  • OTUB1 binding also occludes the RING E3 binding site on UBE2N, thus providing a further component of inhibition
  • UBE2N activity and its interaction with STUB1 precede endocytosis of GHR
  • UBE2N-CHUK signaling axis regulates the molecular program that maintains Treg cell function and prevents Treg cells from acquiring inflammatory phenotypes
  • RNF8 interacts with UBE2N in a manner that is similar to that of the RING-type E3 ubiquitin ligase TRAF6 and the U-box-type E3 ubiquitin ligase, STUB1
  • OTUB1 inhibits Lys-63-linked ubiquitination by binding to a ubiquitin-conjugating enzyme UBE2N
  • C1orf86 preferentially binds the ubiquitin product of RNF8-UBE2N, and this ubiquitin-binding activity and RNF8-UBE2N are both required for recruitment of C1orf86 to interstrand crosslinks
  • implicated in a bipartite role in priming and amplifying lys63-linked ubiquitin chains on histone molecules through coupling with the E3 RNF8 and RNF168
  • OTUB1 is a Lys48-specific deubiquitinating enzyme that forms a complex with E2 ubiquitin (Ub)-conjugating enzymes including UBE2N and UBE2D1
  • ATM-dependent phosphorylation of BCL10 promotes its interaction with and presentation of UBE2N to RNF8, and RNF8-mediated ubiquitination of BCL10 enhances binding of BCL10 and UBE2N to RNF168
  • UBE2N, UBE2L3 and UBE2D2/3 synergistically contribute to PRKN-mediated mitophagy
  • ZNRF1 is an essential E3 ligase implicated in diverse cellular pathways, and that binds UBE2N
  • cell & other
    REGULATION
    inhibited by OTUB1 that inhibits UBE2N and other E2 enzymes
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS