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FLASH GENE
Symbol TXN2 contributors: mct/npt/pgu - updated : 18-05-2009
HGNC name thioredoxin 2
HGNC id 17772
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Txn2
ortholog to rattus txn2
Homologene
FAMILY
  • thioredoxin family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • may be playing an important role in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis
  • playing a crucial role in regulating the mitochondrial apoptosis signaling pathway
  • plays an important role in regulating cellular apoptosis
  • attenuated hypoxia-evoked HIF-1alpha accumulation
  • Trx2 interacts with specific components of the mitochondrial respiratory chain and plays an important role in the regulation of the mitochondrial membrane potential
  • reduce disulfide bonds and other thiol modifications in all cells using a CXXC motif
  • TXN and TXN2 regulate the proliferation and survival of adipose tissue-derived mesenchymal stem cells, and these processes are mediated by the activation of ERK1/2
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with PRDX3 and the TRX2/PRDX3 system functions in parallel with the GSX1 system to protect mitochondria from oxidative stress
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to spina-bifida
    Variant & Polymorphism insertion/deletion Ins/Del polymorphism in the proximal promoter region that altered the transcriptional activity, is associated with spina bifida risk
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS