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FLASH GENE
Symbol TUBGCP2 contributors: mct - updated : 25-11-2019
HGNC name tubulin, gamma complex associated protein 2
HGNC id 18599
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an hydrophobic motif is present in the N-terminus
  • HOMOLOGY
    Homologene
    FAMILY GCP family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • necessary for microtublule nucleation at the centrosome
  • is a core component of gamma-tubulin ring complex (gamma-TuRC) in neuronal migrating cells
  • role of TUBGCP2 as an indispensable component of microtubule nucleation with critical functions in neuronal migration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • TUBGCP2, TUBGCP3 formed complexes with gamma-tubulin in the nucleoli
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • UTP6 N-terminal region indirectly associated with gamma-tubulin through binding with gamma-tubulin complex protein 2 (TUBGCP2) and/or TUBGCP3
  • recognition of gamma-tubulin ring complex integrity is mediated by MZT1, which binds not only to the TUBGCP3 subunit as previously shown, but cooperatively also to other GCPs through a conserved hydrophobic motif present in the N-termini of TUBGCP2, TUBGCP3, TUBGCP5 and TUBGCP6
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCLIS1
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    caused accumulation of cells in G2/M and mitotic delay but did not affect nucleolar integrity
    tumoral     --over  
    in the expression of TUBGCP2 and TUBGCP3 transcripts in glioblastoma cells versus normal human astrocytes
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS