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FLASH GENE
Symbol TIMM22 contributors: mct - updated : 23-05-2019
HGNC name translocase of inner mitochondrial membrane 22 homolog (yeast)
HGNC id 17317
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus Timm22 (94.2 pc)
homolog to murine Timm22 (95.4 pc)
Homologene
FAMILY
  • TIM17/TIM22/TIM23 family
    • CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • mediating the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane
  • constituting the voltage-activated and signal-gated channel, in the TIM22 complex
  • forming a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps
  • majority of inner membrane protein precursors are synthesized in the cytosol, but precursors with a cleavable presequence are imported by the presequence translocase (TIMM23 complex), while other precursors containing internal targeting signals are imported by the carrier translocase (TIMM22 complex)
  • the carrier translocase (TIMM22 complex) inserts multispanning proteins into the inner membrane
  • TIMM22, TIMM23 import pathways depend on the presence of a membrane potential, which is generated by the activity of the respiratory chain
  • TIMM22 complex mediates the import of hydrophobic carrier proteins into the mitochondrial inner membrane
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS mitochondrial transport
    text protein transport
    PATHWAY
    metabolism
    signaling
  • TIM22 protein import pathway mediates the import of membrane proteins into the mitochondrial inner membrane (Hasson 2010)
    • a component
  • TIM22 protein import pathway consists of two intermembrane space chaperone complexes, the TIMM9-TIMM10 and TIMM8A-TIMM13 complexes (Hasson 2010)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting directly with TIMM9, TIMM10/TIM10A and FXC1/TIM10B
  • TIMM29 is required for the stability of the TIMM22 complex and functions in the assembly of TIMM22
  • TIMM29 is required for the structural integrity of the TIMM22 complex and for import of substrate proteins by the carrier translocase
  • AGK functions in a kinase-independent manner to maintain the integrity of the TIMM22 complex, where it facilitates the import and assembly of mitochondrial carrier proteins
  • VDAC1 interacts with carrier precursors arriving in the intermembrane space and recruits TIMM22 complexes, thus ensuring an efficient transfer of the precursors to the inner membrane translocase
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) TIMM22D
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS