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FLASH GENE
Symbol TIAL1 contributors: mct/pgu - updated : 03-10-2011
HGNC name TIA1 cytotoxic granule-associated RNA binding protein-like 1
HGNC id 11804
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three N-terminal RNA recognition motifs (RRMs)
  • a C-terminal glutamine-rich (Q-rich) domain
  • HOMOLOGY
    interspecies homolog to murine Tial1
    homolog to Drosophila CG4787
    homolog to C.elegans C18A3.5a
    intraspecies homolog to TIA-1
    Homologene
    FAMILY
  • a family of RNA-binding proteins
  • CATEGORY RNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,granule
    text cytotoxic granule-associated protein/cytoplasmic granules of cytolytic T-lymphocytes
    basic FUNCTION
  • possessing nucleolytic activity against cytotoxic lymphocyte target cells
  • MYC translational suppressor, involved in the induction of apoptosis
  • repressing PF4 exression
  • inducing DNA fragmentation in permeabilized cells
  • inducing apoptosis in cytolytic lymphocyte (CTL) targets
  • controling proliferation with HNRPD by a MYC-dependent pathway
  • with NANOS3 would play critical functions in posttranscriptional regulations in primordial germ cells soon after their specification
  • TIA1, and TIAL1 are mRNA-binding proteins that can aggregate within granules under specific stress conditions
  • CELLULAR PROCESS cell life, cell death/apoptosis
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcription activating factor
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
  • binding to fragment DNA in permeabilized target cells
  • binding to the PF4 promoter T-cluster and the proximal T-rich region
  • RNA binding specifically to poly(A) homopolymers
    small molecule
    protein
  • TIA1 and TIAL1 proteins are intron-associated positive regulators of SMN2 exon 7 splicing
  • cell & other
    REGULATION
    Other rapid and severe hypoxia caused co-aggregation of TIAL1/TIA1 and these proteins suppressed HIF1A expression
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the thyroid tissues in patients with Graves disease
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS