Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TAS1R1 contributors: mct/npt - updated : 25-04-2017
HGNC name taste receptor, type 1, member 1
HGNC id 14448
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal extracellular binding domain
  • seven transmembrane segments (7TM)
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus Tas1r1 (74.1pc)
    homolog to murine Tas1r1 (74pc)
    intraspecies paralog to TAS1R2
    paralog to TAS1R3
    Homologene
    FAMILY
  • G-protein coupled receptor 3 family
  • TAS1R subfamily
  • sweet receptor subfamily
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • responds to the umami taste stimulus (the taste of monosodium glutamate)
  • with TAS1R3, believed to function in combination as a heteromeric glutamate taste receptor in humans (Chen 2009)
  • with TAS1R3, likely contributes to human umami taste perception (Chen 2009)
  • TAS1R1/TAS1R3 are a direct sensor of the fed state and amino acid availability
  • TAS1R1 receptor subunit acts as an umami taste receptor in combination with its partner, TAS1R3
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction , sensory transduction/taste
    sweet receptor
    a component
  • forming an heterodimer with TAS1R3
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • L-amino acids "sweet" ligands
  • TAS1R1-TAS1R3 (T1R1-T1R3) can sense extracellular amino acids, activate MTOR, and inhibit autophagy
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to individual taste sensitivity to glutamate
    Variant & Polymorphism SNP , other
  • TAS1R1-TAS1R3 receptor variants found in human fungiform papillae might contribute to inter-individual differences of sensitivity to L-glutamate (Raliou 2009)
  • SNP G1114A more frequent in tasters to glutamate (Raliou 2009)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS