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FLASH GENE
Symbol TAF9B contributors: mct - updated : 16-06-2020
HGNC name TAF9-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
HGNC id 17306
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies paralog to TAF9
Homologene
FAMILY TAF9 family
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • involved in transcriptional activation as well as repression of distinct but overlapping sets of genes
  • may have a role in gene regulation associated with apoptosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TAF9B is a coactivator for the TP53 protein
  • TAF9B binds to both promoters and distal enhancers of neuronal genes, partially co-localizing at binding sites of OLIG2, a key activator of motor neuron differentiation
  • through its acidic transactivation domain (TAD), RELA has the capacity to form interactions with several different transcriptional regulatory proteins, including GTF2B, GTF2H1, EP300 and TAF9B
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS