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FLASH GENE
Symbol SEMA4C contributors: mct/npt - updated : 21-09-2009
HGNC name sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
HGNC id 10731
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 1 Ig-like C2-type (immunoglobulin-like) domain
  • a PSI domain
  • a SEMA domain
  • a cytoplasmic domain containing a proline-rich region that may interact with some signaling proteins
  • HOMOLOGY
    Homologene
    FAMILY
  • semaphorin family
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may play a role in axon guidance
  • may function in the cortical neurons as a bi-directional transmembrane ligand through interacting with DLG4
  • may be involved in regulating cell-sorting in the formation and regeneration of the periodontal attachment structure (Lallier 2004)
  • transmembrane semaphorin proteins which regulate axonal guidance in the developing nervous system (Wu 2007)
  • promotes terminal myogenic differentiation in a MAPK14-dependent manner (Wu 2007)
  • plays an important role in terminal myogenic differentiation, and during neurogenesis (Wu 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with GIPC PDZ domain
  • interacting with DLG3, DLG4, in the brain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS