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FLASH GENE
Symbol ACER3 contributors: mct - updated : 03-07-2018
HGNC name alkaline ceramidase 3
HGNC id 16066
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies homolog to murine Acer3 (88.4pc)
homolog to rattus Phca (88.0pc)
intraspecies homolog to ACER2, ACER1
Homologene
FAMILY
  • alkaline ceramidase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text
  • integral membrane protein
  • localized to the endoplasmic reticulum and the Golgi complex
  • basic FUNCTION
  • hydrolyzes only phytoceramide into phytosphingosine and free fatty acids
  • hydrolyzing unsaturated long-chain ceramides (Hu 2010)
  • coordinates with ACER2 to regulate cell proliferation and survival (Hu 2010)
  • alkaline ceramidase activity is important for the generation of SPH, the S1P precursor in erythrocytes
  • contributes to acute myeloid leukemia (AML) pathogenesis
  • play likely a protective role in sphingolipid homeostasis in the brain
  • is involved in motor coordination-associated Purkinje cell degeneration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by Ca2+
    inhibited by Zn2+
    ASSOCIATED DISORDERS
    corresponding disease(s) PLDECO
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    alkaline ceramidase inhibition is an option to treat AML
    ANIMAL & CELL MODELS
    Acer3 deficient mice demonstrated impairment in motor coordination and balance capabilities