SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
| intracellular,cytoplasm,organelle,Golgi
|
text
| integral membrane protein |
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localized to the endoplasmic reticulum and the Golgi complex |
basic FUNCTION
| hydrolyzes only phytoceramide into phytosphingosine and free fatty acids |
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hydrolyzing unsaturated long-chain ceramides (Hu 2010) |
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coordinates with ACER2 to regulate cell proliferation and survival (Hu 2010) |
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alkaline ceramidase activity is important for the generation of SPH, the S1P precursor in erythrocytes |
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contributes to acute myeloid leukemia (AML) pathogenesis |
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play likely a protective role in sphingolipid homeostasis in the brain |
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is involved in motor coordination-associated Purkinje cell degeneration |