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FLASH GENE
Symbol PDE8A contributors: mct - updated : 18-12-2018
HGNC name phosphodiesterase 8A
HGNC id 8793
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • N terminal REC domain
  • a PAS domain
  • a C catalytic domain
  • HOMOLOGY
    Homologene
    FAMILY
  • cyclic nucleotide phosphodiesterase family
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    text
  • largely associated with mitochondria
  • basic FUNCTION
  • may would be involved in signal transduction
  • is a novel cardiac phosphodiesterases that controls one or more pools of cAMP implicated in regulation of Ca(2+) movement through cardiomyocyte
  • potential role for PDE8A in cAMP signaling related to pain transmission, motor function, cognition and olfaction
  • PDE8A supports HIV-1 replication in macrophages and that this effect is mediated at the level of reverse transcription
  • cyclic nucleotide PDEs play important role in the achievement of meiotic competency by reducing intraoocyte cyclic nucleotides level in mammalian oocytes
  • regulates T cell motility
  • exerts part of its control of T cell function through RAF1 kinase signaling pathway
  • controls CD4+ T cell motility through the PDE8A-Raf-1 kinase signaling complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • both PDE8A and PDE8B play essential roles to maintain low cAMP levels, thereby suppressing resting steroidogenesis by keeping cholesterol-ester hydrolase (CEH)/hormone-sensitive lipase (HSL) inactive and STAR protein expression low
  • PDE8A is a physiological regulator of RAF1 signaling in some cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS