basic FUNCTION
| may would be involved in signal transduction |
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is a novel cardiac phosphodiesterases that controls one or more pools of cAMP implicated in regulation of Ca(2+) movement through cardiomyocyte |
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potential role for PDE8A in cAMP signaling related to pain transmission, motor function, cognition and olfaction |
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PDE8A supports HIV-1 replication in macrophages and that this effect is mediated at the level of reverse transcription |
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cyclic nucleotide PDEs play important role in the achievement of meiotic competency by reducing intraoocyte cyclic nucleotides level in mammalian oocytes |
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regulates T cell motility |
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exerts part of its control of T cell function through RAF1 kinase signaling pathway |
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controls CD4+ T cell motility through the PDE8A-Raf-1 kinase signaling complex |