SUBCELLULAR LOCALIZATION
| plasma membrane,junction,adherens
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus,chromatin/chromosome
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| intracellular,nuclear envelope,int
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| text
| dynamically associating with chromatin during the cell cycle |
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nuclear periphery proteins LMNA, TMPO and BANF1 relocate to the spindle and the cell cortex in mitosis  |
| basic FUNCTION
| playing an important role, together with LMNA, in the nuclear anchorage of RB1 |
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may be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly |
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playing a role with OIP5 during cell cycle exit, in which OIP5 acts upstream of TMPO |
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serves likely as a transcriptional co-regulator, which controls muscle specific gene expression during muscle regeneration, muscle remodeling and stress response |
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nuclear protein that connects the nuclear lamina with chromatin |
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and nucleoplasmic lamins are regulators of adult stem cell function and tissue homeostas |
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LMNA, TMPO and BANF1 are assembled into a protein complex during mitosis in order to regulate assembly and positioning of the mitotic spindle |
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in addition to its cell cycle-inhibiting function with LMNA, TMPO can also regulate extracellular matrix components independently of LMNA, which may help explain the proliferation-promoting function of TMPO in cells expressing progerin (pMID: 26443848) |
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novel role of nucleoplasmic lamin A/C and TMPO in regulating euchromatin |
