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FLASH GENE
Symbol CA5A contributors: mct - updated : 29-03-2014
HGNC name carbonic anhydrase VA, mitochondrial
HGNC id 1377
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated MetalloP
HOMOLOGY
Homologene
FAMILY eukaryotic-type carbonic anhydrase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,matrix
basic FUNCTION
  • reversibly hydrating CO2 in cellular ion transport and pH homeostasis
  • participates in the detoxification of ammonia produced in the gastrointestinal tract by providing bicarbonate to carbamyl phosphate synthetase
  • CA5A, CA5B are pivotal in providing HCO3&
  • 8722; for multiple mitochondrial enzymes that catalyze the formation of essential metabolites of intermediary metabolism in the urea and Krebs cycles
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text putatively involved in ureagenesis, gluconeogenesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CA5AD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS