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FLASH GENE
Symbol NTSR2 contributors: mct - updated : 27-05-2013
HGNC name neurotensin receptor 2
HGNC id 8040
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a short cytoplasmic N-terminal sequence with no clear potential glycosylation sites.
  • a cysteine residue conserved in the human, mouse, and rat proteins in each of the extracellular loops between the 7 transmembrane domains
  • HOMOLOGY
    intraspecies homolog to NTSR1
    Homologene
    FAMILY family 1 of G-protein coupled receptors
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • activating a phosphatidylinositol-calcium second messenger system
  • heterodimerization with NTSR1 may play a physiological role in the regulation of their cell surface density, and hence of their responsiveness to neurotensin, in central nevous system
  • novel function of NTSR2 in the regulation of NTSR1 activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in B cell leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS