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FLASH GENE
Symbol NPM3 contributors: SGE/npt/pgu - updated : 08-03-2010
HGNC name nucleophosmin/nucleoplasmin 3
HGNC id 7931
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated PhosphoP
HOMOLOGY
interspecies homolog to murine Npm3 (86.9pc)
homolog to rattus Npm3 (85.0pc)
Homologene
FAMILY
  • nucleophosmin/nucleoplasmin family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • lacking intrinsic histone chaperone activity
  • inhibits histone assembly activity of NPM1 and dramatically enhances transcription
  • the NPM proteins (NPM1, NPM2, NPM3) cooperatively regulate chromatin disassembly and assembly in the early embryo and in somatic cells
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TNP2
  • NPM3 suppressed the RNA-binding activity of NPM1, which enhanced the nucleoplasm-nucleolus shuttling of NPM1 in somatic cell nuclei
  • beyond their important role in the remodeling of paternal chromatin in the early stages of embryogenesis, NPM2 and NPM3 and NASP members can interact with a plethora of proteins in addition to histones in somatic cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS