protein
| WNT-induced intracellular negative regulator of canonical WNT signaling |
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NKD1 binds to CTNNB1 and prevents its nuclear accumulation |
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NKD1 is recruited to the WNT signalosome with DVL2, where it becomes activated to move into the cytoplasm to interact with CTNNB1, inhibiting its nuclear accumulation |
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FGF2 mediates hepatic progenitor cell formation during human pluripotent stem cell differentiation by inducing the WNT antagonist NKD1 |
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NKD1 repressed hepatocellular carcinoma (HCC) cell proliferation by inducing TP53 expression |