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FLASH GENE
Symbol NASP contributors: mct - updated : 09-09-2013
HGNC name nuclear autoantigenic sperm protein (histone-binding)
HGNC id 7644
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • TRP1-2-3 (tetratricopeptid) repeats
  • from coiled coil
  • glu-rich (acidic)
  • leucine-zipper
  • nuclear localization signal
  • HOMOLOGY
    interspecies ortholog to murine Nasp
    homolog to C.elegans F58G11.1A
    homolog to xenopus N11N2
    Homologene
    FAMILY nuclear autoantigenic sperm protein (NASP) family
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,chromatin/chromosome,nucleosome
    text tNASP : Golgi and acrosome nucleus, 5NASP:nuclear localization
    basic FUNCTION
  • transporting histones into the nucleus of dividing cells (isoform 3)
  • directly promotes nucleosome assembly, providing compelling evidence that sNASP is a bona fide histone chaperone for H3.H4
  • specific function for the histone chaperone NASP to fine-tune a reservoir of soluble H3-H4 in the histone supply chain
  • unique genuine chaperone for histone H1
  • CELLULAR PROCESS cell cycle, division
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • GTP
  • protein
  • binding to H1 histones
  • beyond their important role in the remodeling of paternal chromatin in the early stages of embryogenesis, NPM2 and NPM3 and NASP members can interact with a plethora of proteins in addition to histones in somatic cells
  • TRA2B is involved in splicing processes of NASP
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS