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FLASH GENE
Symbol MYH7B contributors: mct - updated : 24-03-2020
HGNC name myosin, heavy polypeptide 7B, cardiac muscle, beta
HGNC id 15906
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY motor/contractile
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
text
  • is localized to dendritic spines
  • MYH7B and MYH15, are expressed in muscle spindles
  • basic FUNCTION
  • having a motor activity
  • conforms to a sarcomeric motor consensus, which suggests it has a unique function relative to the nonmuscle isoforms expressed in neurons
  • maintains synaptic strength in hippocampal neurons through an actin-dependent mechanism
  • MYH7B and MYH10 have distinct and overlapping effects on spine morphology
  • is necessary for steady-state synaptic transmission in hippocampal neurons
  • MYH7B and MYH15 play a prominent role in the heart and skeletal muscles of certain species like chicken and snakes, whereas in mammals, the only muscles that these myosin motors function in are highly specialized muscles
  • may have a role that uniquely fits a contractile requirement of the specialized muscles
  • expression of MYH7b protein in the mammalian heart has been inhibited during the evolution of mammals most likely to prevent the development of a severe cardiomyopathy that is sexually dimorphic
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • maintains excitatory synaptic function by regulating F-actin filaments associated with AMPA receptors
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LVNC13
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascularaquiredheart failure
    activation of myosin by omecamtiv mecarbil may provide a new therapeutic approach for systolic heart failure
    ANIMAL & CELL MODELS