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FLASH GENE
Symbol LASP1 contributors: mct - updated : 14-01-2014
HGNC name LIM and SH3 protein 1
HGNC id 6513
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • LIM (cysteine-rich LIM/double zinc finger motifs)
  • SH3 domains
  • an actin-binding domain in the core of the protein
  • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text
  • localized in the cytoplasm and nuclei of tumor epithelia
  • predominantely present at focal adhesions, however, a second pool of LASP1 molecules is also found at lamellipodia and vesicle-like microdomains in the cytosol
  • basic FUNCTION
  • potentially involved in a signaling pathway for the organization of the cytoskeleton
  • may play an important role in the organization of focal adhesions with NEBL and ZYX
  • LASP1 and NEBL, are important during early embryo- and fetogenesis and are highly expressed in the central nervous system of the adult
  • NEBL and LASP1 have distinct roles in the actin cytoskeleton
  • role in chondrocyte differentiation during cartilage to bone transition
  • actin-binding, signaling pathway-regulated phosphoprotein that is overexpressed in several cancers
  • is potenbtially a general mediator of CXC chemokine mediated chemotaxis
  • functional role for LASP1 in the progression and metastatic dissemination of medulloblastoma
  • actin-binding protein that is known to regulate cytoskeleton architecture and cell migration
  • recruited in early steps of podosome assembly
  • multidomain protein predominantly localized at focal contacts, where it regulates cytoskeleton dynamics and cell migration
  • plays a significant role in the formation of several malignant tumours
  • actin-binding protein which is overexpressed in many types of cancers and plays important roles in cancer progression
  • may play an important role in the pathogenesis of esophageal squamous cell carcinoma(ESCC)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • novel component and regulator of podosomes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • actin binding
  • interacting with ZYX and NEBL (SH3 domains from LASP1 and nebulin can also interact with zyxin, but the SH3 domains from more distantly related proteins such as vinexin and SNX9 do not)
  • through Kelch repeats, KLHL41 interact directly with LASP1 in membrane ruffles at the tips of pseudopodia, where both proteins are necessary for pseudopodial elongation
  • LASP1 interaction with CXCR2 is critical for CXCR2-mediated chemotaxis
  • LASP1-binding partner, TJP2, having a role in the signal transduction pathway of LASP1 nucleo-cytoplasmatic shuttling
  • interplay between LASP2 and LASP1 could be an adhesion regulatory mechanism
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in breast cancer
    tumoral     --over  
    associated with poor overall survival in hepatocellular carcinoma patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    promise as a treatment target in esophageal squamous cell carcinoma
    cancerdigestive 
    might be a promising target in the treatment of patients with colorectal cancer (CRC) with growth and metastasis of CRC
    ANIMAL & CELL MODELS