basic FUNCTION
| scaffold protein that targets to the tight junction in epithelia |
|
required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton |
|
involved in intracellular signaling cascade |
|
required for correct localization of CRB1 at the subapical region in polarized Muller glia cells |
|
may play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells |
|
playing a role in the biogenesis of adherens junction |
|
may be essential for the maintenance of epithelial cell polarity |
|
polarity protein which plays an essential role in the radial and longitudinal extension of the myelin sheath, likely involving a functional role in membrane protein trafficking |
|
roles in cell survival through interactions with MTOR signaling |
|
participates to the optimal activation of NFKB1 following TCR stimulation |
|
important functions in the retinal pigment epithelium in addition to the neural retina |
|
indispensible role in retinal development, likely involving the maintenance of retinal polarity and survival of retinal neurons |
|
its function is likely essential for laminar formation in both embryonic and postnatal retinas |
|
encodes a scaffolding protein essential for the assembly and function of the CRB polarity complex in epithelial tissues, including the retina |
|
specifically required for full maturation of photoreceptor cells |
|
role of the canonical polarity protein MPP5 in radial sorting of axons by Schwann cells |
|
is not only essential for cerebellum organogenesis, but also for preventing premature differentiation and thus maintaining progenitor pools in cerebellar germinal zones, including cerebellar granule neuron precursors in the external granule layer |
|
is a novel intrinsic factor that regulates the generation of cerebellar cells and its deficiency is a potential inhibitor of overactive mitogenic signaling |
|
core component of the apical membrane-determining CRB complex in the nephron |
|
functions as a dose-dependent upstream regulator of the crosstalk between Hippo- and TGFB1-mediated signaling |
|
new function of PALS1 as a key inhibitor of cell migration and metastasis of colorectal cancer cells |
|
|